We use our compaction simulator to predict the manufacturability of clients’ potential tablet products. Using a few grams of material and high-speed press simulations, we can de-risk scale-up and save money.
Early intervention with press simulation can avoid tablet capping, lamination, and other serious production issues. Merlin utilises decades' worth of research in compaction science. For clients, this means better understanding and better prediction.
Merlin can identify potential manufacturing compression issues at the product formulation stage while there is still time to make changes, making costly scale-up disasters a thing of the past.
De-risk your chances of scale-up issues by compressing the powder at production speeds using production press simulation profiles. You can assess the suitability of your product with as little as 20g of development formulation, compared with manufacturing much larger quantities of expensive material required to run a press only to find that it does not make a good tablet. This is especially useful if the material is in short supply or there are time constraints.
The development formulation is compressed over a range of compaction forces and compression forces, densities and compact properties measured. The results are compared to key performance indicators to assess scale-up risk.
Tablet Capping and Lamination
Assess the factors which cause tablet capping and lamination to improve your formulation or manufacturing processes. Troubleshoot production issues to understand the causes of compression issues. Discover more about tablet capping and lamination here.
Press Simulations
Using the Phoenix press-profiler software Merlin can replicate the effects of a wide range of production presses. If you want peace of mind to know if your formulation will work on your preferred press at your target speed, it can be done on a significantly smaller scale.
Tooling trials
When trying out new tablet shapes, it can be expensive to buy a full set of tools. A compaction simulator can be used to assess the tooling and compact properties using only one set – saving money and time. By using a compaction simulations, we can evaluate and optimise tablet designs efficiently. We can use any standard B, D and F configurations.
Related services
Other tests to consider depending on the material and application, may include API characterisation, powder flowability, compression science and potentially true density testing.
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