With the Mixer Torque Rheometer (MTR) we investigated the quantity of water needed for granulation by utilising the Binder addition function. Following this, an analysis of the mixing time was conducted to evaluate the robustness of the Mefenamic acid formulation.
Test 1
The initial test focused on assessing the variation in formulation behaviour with different amounts of granulating fluid added. The binder was present in within the blend, while water served as the granulating fluid.
Once completed 40g of the blend was utilized from the 100g batch made for the investigation. The reproducibility of results instilled confidence in identifying the maximum quantity of liquid that could be incorporated prior to the onset of over-granulation. The optimal peak torque was recorded between 1.25 and 1.5 ml/g across both test runs.
Test 2
In the subsequent phase of the analysis, sensitivity to mixing time was explored by the addition of various volumes of water.
The torque demonstrated a rapid increase during the initial 100 seconds of mixing, after which the rate of increase slowed. Torque continued to rise throughout the mixing period, indicating the formulations resilience to over-mixing. When a reduced volume of water was used, torque escalated rapidly over an extended timeframe (approx. 150 seconds) before the rate of increase diminished. The peak torque was lower compared to tests involving higher water additions, yet torque remained higher throughout the mixing period, further demonstrating the formulations robustness.
When under-granulation was examined, it was observed that insufficient water led to a swift rise in torque over an extended duration (250 seconds), reaching a maximum level where additional mixing did not enhance, wet mass strength.
Ask Us For A Consultation Call
Or you can call us on +44(0)1384 900 265
